Cymbalta indications for use

Pharmachologic effect
Cymbalta has an antidepressant effect. Duloxetine is an antidepressant, a serotonin reuptake inhibitor and norepinephrine, and weakly inhibits dopamine capture, without having a significant affinity for histaminergic, dopaminergic, cholinergic and adrenergic receptors. The mechanism of action of duloxetine in the treatment of depression is to suppress reuptake of serotonin and norepinephrine, thereby enhancing serotonergic and noradrenergic neurotransmission in the CNS. Duloxetine has a central mechanism for suppressing pain, which primarily manifested by increased pain threshold when the etiology of neuropathic pain syndrome.

Cymbalta, indications for use
Depression.
Pain form of diabetic neuropathy.
Contraindications
Hypersensitivity to the drug.
Concomitant use with monoamine oxidase inhibitors (MAOIs).
Uncompensated angle-closure glaucoma
Carefully

In acute mania / hypomania, seizures, mydriasis, abnormal liver or renal function, with the likelihood of suicide attempts.

Dosing and Administration
Cymbalta is prescribed orally, regardless of food intake.

The capsules should be swallowed whole without chewing or crushing. Cymbalta can not add to food or mixed with liquids as this may damage enteric capsule shell.

The recommended starting dose of Cymbalta is 60 mg 1 time a day. If necessary, the dose may be increased to a maximum dose - 120 mg per day in 2 divided doses. Systematic evaluation of receiving Cymbalta at a dose over 120 mg has not been evaluated.

In end-stage chronic renal insufficiency (creatinine clearance less than 30 ml / min), the initial dose of Cymbalta is 30 mg 1 time a day.

Pregnancy and breast-feeding
Due to insufficient experience with Cymbalta during pregnancy, the drug should be used during pregnancy only if the potential benefit to the patient is much higher than the potential risk to the fetus. Patients should be warned that in case of pregnancy or planning during duloxetine treatment, they need to inform your doctor.

Given the lack of experience with duloxetine in women during breast-feeding is not recommended to breast-feeding during treatment with duloxetine.

Side effects
The most commonly (10%), dizziness (excluding vertigo), dry mouth, nausea, constipation, sleep disorders (insomnia or drowsiness), headache (less frequently than with placebo). Less commonly (1-10%): diarrhea, vomiting, tremors, loss of appetite, weight loss, weakness, sweating, flushing, blurred vision, anorgasmia, decreased libido, delayed and abnormal ejaculation and erectile dysfunction. The slight increase in the concentration of fasting blood glucose in patients with painful diabetic neuropathy form. Dizziness, nausea, headache observed as a frequent adverse effects of the abolition of duloxetine.

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The pharmacological action of the drug Cymbalta Cymbalta According to the instruction refers to a group of antidepressants. The drug inhibits the reuptake of serotonin and norepinephrine, resulting in increased noradrenergic and serotonergic neurotransmission in the central nervous system. Besides the drug contributes to the suppression of pain, thereby increasing pain threshold in patients with pain of neuropathic origin. Cymbalta is well absorbed after oral administration. The maximum concentration of drug in the blood serum is determined after 6 hours after ingestion. In the body, duloxetine is metabolized. Cymbalta withdrawal of the drug in the kidneys. The half-life of 12 hours. Indications Cymbalta According to the instructions recommended to prescribe for depression and painful form of diabetic neuropathy. Contraindications Cymbalta hypersensitivity to ingredients; angle-closure glaucoma (uncompensated); simultaneous reception of MAO inhibitors (monoamine oxidase). With caution the drug should be used during exacerbation of mania, epileptic seizures, abnormal liver / kidney function, mydriasis, and in patients with a tendency to suicide.

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The doctor sent a medical psychologist for an examination, as a result of violations of thinking was not found with the same psychologist, spent a year of psychotherapy, trying with help sessions to find answers to the questions: what I'm sick? when wake up feeling? Do I not schizophrenia? For the search for the truth tried several physicians, all utverzhali "schizophrenia speak prematurely." And I'm afraid that I was she, then all life on smarku ... I'm 25 years old, I have a prestigious higher education, heredity, clean, except that my father drank a lot earlier. Recently, still lay in the hospital, from which he emerged with a diagnosis of depression. Now I accept Eglonil and Lerivon to lerivon drink Cymbalta. The drugs do not help, drink them only in order to prevent a possible breakdown. Feeling hopeless patient. Complaints to date: Indifference, zero imagination, I can not think figuratively, tuplyu, subjectively is not enough memory, I do not feel my age. Two questions for you:
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