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Prozac (fluoxetine) - bicyclic antidepressant, one of the well-known representatives of the SSRI group (). This medication improves mood, reduces feelings of fear, anxiety, tension, and also eliminates dysphoria, no sedative effect on the central nervous system, orthostatic collapse, not kardiotoksichen.
Main characteristics
The drug is available in the form of hard gelatin capsules, each of them contains 20 mg fluoxetine hydrochloride.
pharmacological effect
The active component is a bicyclic antidepressant fluoxetine (propylamine derivative), which belongs to the SSRI group.
The drug at the minimum level has an effect on dopaminergic, histamine (H1), α-adrenergic and cholinergic receptors, thereby side effektyposle egoprimeneniya minimal.
Fluoxetine increases the concentration of the neurotransmitter serotonin in the brain, thereby stimulating effect on the nervous system is increased.
Pharmacokinetics
After intake of rapidly absorbed from the gastrointestinal tract (95%), eating almost no inhibitory effect on absorption.
Fluoxetine peak plasma concentration achieved after 6-8 hours after oral administration Bioavailability -. 60% higher. Fluoxetine is able to accumulate in the tissues and distributed throughout the body, easily penetrates through the BBB.
Prozac is derived mainly by the liver and urine (as a metabolitov- norfluoxetine, and other).
Prozac
Application area
The official summary stated that the capsules for oral administration of Prozac displayed for the relief of the following offenses:
obsessive-compulsive disorder;
depressions of different nature (weak, moderate, severe).
The drug is effective in eating disorders (bulimia nervosa), obsessive-compulsive disorder, premenstrual dysphoric disorder, with the purpose of relief of other mental disorders (in the complex) - schizoaffective syndromes, schizophrenia and biopolyarnyh disorders, alcoholism. Prozac for depression is more effective with motornoyzatormozhennostyu, patologicheskoysonlivosti, medication can enhance the clinical course of mental disorders in patients with morbid excitement, anxiety and insomnia, because such patients it is prescribed with caution.
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Food intake has no significant impact on the absorption of fluoxetine from the gastrointestinal tract, it can be taken regardless of meals.
Do not suddenly cancel the antidepressant agent because it is fraught by withdrawal of medication.
For patients with serious disorders of the kidneys and liver, atakzhe comorbidities, or taking other drugs, Prozac dose should be titrated according to individual parameters.
Treatment of children
At this point the medicament is forbidden to use in pediatric practice.
The probability of an overdose of medication
As it is written in on the application, the drug Prozac instructions exceeding the dose of 80 mg leads to the symptoms:
Respiratory system: a violation of the respiratory function;
ZHKT- vomiting, nausea;
CCC- irregular heartbeat, arrhythmia, heart failure;
TSNS- excessive excitation, coma.
These symptoms occur very often, the probability of death is low enough.
Therapeutic measures:
Appointment of symptomatic and supportive therapy;
Control of breathing and heart activity.
There is no specific antidote.
Cancel the drug
The medicament as Prozac and other SSRIs representatives differ pronounced withdrawal syndrome (often paroxetine) usually takes place in such a condition for 1-7 days.
It is necessary to avoid abrupt withdrawal of the drug, a decision to stop the treatment adopted by the attending physician by gradually reducing the dosage.
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The degree of enthusiasm for the new tablets can be measured by the product of the writer and journalist Elizabeth Vurtsel - novel "Prozac Nation," which quickly became a bestseller and later made into a movie. Vurtsel long time she took Prozac and described some of the same symptoms from his long-term use, that most of the other patients. In particular, it is known that while Prozac and muffles anxiety, and mental pain, after a while it makes a person insensitive and joyous moments of life. "Gradually the consumer Prozac turns into a vegetable, unable to feel at all any emotions", - she said.
Most antidepressants - a selective serotonin reuptake inhibitor, which are able to artificially delay the neurotransmitter in the brain as long as possible, causing a feeling of euphoria. Many researchers believe that the lack of it in the brain of this substance leads to depression and causes to see the world in gray and black tones.
Action Prozac over time leads to serious mental disorders: get used to the drug, the level of serotonin synthesized by the body decreases, and the patient is forced to move to another, often much stronger drug. And so it is with almost all antidepressants, including the latest.
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