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Zoloft, paroxetine and sertraline are used to treat severe depression

Zoloft, paroxetine and sertraline are used to treat severe depression, which was not caused by the use of other drugs, alcohol or high stress (such as the death of loved ones). They have proven effective for many patients, including those to whom other drugs do not help. Fluoxetine is the drug of choice of patients who are subject to fatigue, low blood pressure, dry mouth, and constipation caused by other antidepressants. In case of overdose it is safer a number of other antidepressants, but there is no evidence that the death rate from suicide has decreased as a result of the widespread use of fluoxetine and other drugs of selective inhibitors of reverse neuronal capture. There is only limited data on safety and efficacy of fluoxetine in the treatment of the elderly.
Fluoxetine and other drug group of selective inhibitors of reverse neuronal capture can reduce the risk of suicide in people with depression. However, some researchers argue that the fluoxetine actually cause suicidal thoughts in some patients, although it should be noted that these data were not confirmed. In 1991, the Public Sitizen's Health Research Group petitioned the FDA stating the need to include in the annotation to the drug warning to doctors that a small number of people taking this drug, experienced an intense, bright thoughts of suicide, as well as excitement and a penchant for impulsive actions after you start taking this medicine. You should not use this drug to treat mild depression or anxiety, as well as a sedative.
Overview of randomized trials of 64 control by comparing the group of selective inhibitors of reverse neuronal uptake with other antidepressants such as imipramine found similar positive effects in both the old and new drugs have. In summing up Zoloft of all clinical trials, the so-called meta-analysis, it became clear that the new drugs do not have any clear advantages over the old. The negative effects of the old and new drugs are different in all but withdrawal. For example, the probability of sedation, anticholinergic effect and cardiac arrhythmias by using selective inhibitors of reverse neuronal uptake less than conventional antidepressants. On the other hand, the negative effects of selective inhibitors of reverse neuronal uptake affect the gastrointestinal tract causing diarrhea and nausea, and can lead to insomnia, excitation, extrapyramidal disorders (Parkinson drug) and withdrawal syndrome.
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According to the instructions Zoloft is taken once daily in the morning or in the evening. Judging by the reviews, the effectiveness of the drug is independent of food intake. Treatment of depression and obsessive-compulsive disorder begin with a dose of 50 mg per day, the treatment of posttraumatic stress disorder, panic disorder and social phobia - with a lower dose of 25 mg, which can be increased through week 2 times. This regimen User Zoloft reduces the incidence of early adverse effects of treatment, which are characteristic of panic disorder. Most often, the first positive effect is observed after a week use of the drug, and resistance develops within a few weeks. If necessary to achieve optimum therapeutic effect received dose can be increased to 200 mg per day. The initial daily dose of Zoloft in the treatment of obsessive-compulsive disorder for children aged 6-12 years is 25 mg, and in the age of 13-17 years - 50 mg. Adjusting the dose elderly and renal impairment is not required, as in hepatic dysfunction dose Zoloft, or analogs, it is recommended to reduce. In case of overdose, even at high doses of Zoloft for reviews of serious violations of causes and symptoms of overdose most commonly manifested as increased sweating, drowsiness, nausea, vomiting, dizziness, tachycardia, agitation, diarrhea, myoclonus, agitation, and hyperreflexia. However, when taking Zoloft in conjunction with other drugs or alcohol poisoning can cause serious, even fatal, or coma.
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Side effects According to many reviews Zoloft can cause various side effects, which are manifested as dry mouth, dyspeptic symptoms, abdominal pain, hepatitis, pancreatitis, jaundice, liver failure and loss of appetite. Much less with prolonged use of Zoloft develop asymptomatic increase of transaminases in blood serum; Tachycardia, palpitations and a feeling of hypertension; Muscle cramps and arthralgia; Paresthesia, extrapyramidal disorder, euphoria, involuntary muscle contractions, syncope, tremor, headache, drowsiness, headache, nightmares; Hallucinations, dizziness, insomnia, anxiety, loss of libido, agitation, psychosis, and coma; Bronchospasm and yawning; Menstrual disorders and sexual dysfunction, galactorrhea, gynaecomastia, priapism; Incontinence or retention of urine; Mydriasis, blurred vision, ringing in the ears, periorbital edema; Hypothyroidism and hyperprolactinemia; Urticaria, pruritus, anaphylactoid reactions, angioedema, swelling of the face; Alopecia, skin redness, or "tides" of blood to the face, purpura, photosensitivity reaction, increased sweating; Peripheral edema, a decrease or increase in body weight, weakness, increased cholesterol level in the blood serum.

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